Patents
1. Heterocyclic compounds as ENT inhibitors and compounds for use in the treatment of cancers
Deligny, M. ; Van Der Plas, S.; Houthuys, E.; Rowley, M. WO2024134541
2. Preparation of macrocyclic compounds having ENT1 inhibiting activity
Deligny, M.; Houthuys, E. ; Talbot, E. Moroglu, M. WO2023059739
3. Processes for preparing a macrocyclic compound having ent1 inhibiting activity
Huang, X.; Deligny, M.; Talbot, E.; Moroglu, M.; Roche, D.; Lemoine, H.; Yuan, C.; Shang, D. WO2023056910
4. Method for the production of thiocarbamate derivatives A2AR inhibitors
Deligny, M.; Crosignani, S.; Jiao, X.; Jiang, X. WO2022089572
5. Pyrimido[5,4-d]pyrimidine derivatives as ENT inhibitors for the treatment of cancers, and combination thereof with adenosine receptor antagonists
Deligny, M.; Crosignani, S.; Houthuys, E. WO2021170797
6. Macrocyclic diamine derivatives as ENT inhibitors for the treatment of cancers, and combination thereof with adenosine receptor antagonists
Deligny, M.; Crosignani, S.; Houthuys, E. WO2021204896
7. Preparation of indole-, azaindole-, benzothiophene- and benzofuran-3-sulfonamides as GPR17 modulators for the treatment of CNS diseases
Mueller, C.; Pegurier, C.; Deligny, M.; El-Tayeb, A.; Hockemeyer, J.; Ledecq, M.; Mercier, J.; Provins, L.; Boshta, N.; Bhattarai, S.; Namasivayam, V.; Funke, M.; Schwach, L.; Gollos, S.; Von Laufenberg, D.; Barre, A WO2018122232
8. Preparation of fused hexacyclic imidazole derivatives as modulators of TNF activity
De Haro Garcia, T.; Deligny, M.; Heer, J.; Horsley, H.; Jadot, S.; Keyaerts, J. WO2017167995
9. Fused pentacyclic imidazole derivatives as modulators of TNF activity
Deligny, M.; Heer, J.; Kayaerts, J.; Lepissier, L.; Lowe, M. WO2017167994
10. Fused pentacyclic imidazole derivatives as modulators of TNF activity
Deligny, M.; Heer, J. WO2017167993
11. Fused pentacyclic imidazole derivatives
De Haro Garcia, T.; Deligny, M.; Heer, J.; Quincey, J.; Xuan, M.; Zhu, Z.; Brookings, D.; Calmiano, M.; Evrard, Y.; Hutchings, M.; and al WO2016050975
12. Fused tricyclic imidazole derivatives as modulators of TNF activity and their preparation
Alexander, R.; Brown, J.; Deligny, M.; Heer, J.; Jackson, V.; Jadot, S.; Kroeplien, B.; Mac Coss, M.; Sabnis, Y.; Swinnen, D.; and al WO2015086527
Alexander, R.; Brace, G.; Brown, J.; Calmiano, M.; Chovatia, P.; Deligny, M.; Gallimore, E.; Heer, J.; Jackson, V.; Kroeplien, B.; and al WO2015086526
Alexander, R.; Calmiano, M.; Defays, S.; Durieu, V.; Deligny, M.; Heer, J; Jackson, V; Keyaerts, J; Kroeplien, B; Mac Coss, M; and al WO2015086525
13. Imidazopyridine derivatives as modulators of TNF activity
Deligny, M.; Heer, J.; Jackson, V.; Kroeplien, B.; Lecomte, F.; Porter, J. WO2015086509
14. Preparation of benzoimidazole compounds with antiparasitic activity for the treatment of infectious diseases caused by apicomplexans
Deligny, M.; Saidani, N; Bonneau, A.-L.; Botte, C.; Hardre, H.; Rousseau, B.; Vial, H.; Mercier, C.; Lopez, R.; Marechal, E. WO2008146172
15. Use of compounds having a monogalactosyldiacylglycerol synthase inhibitory activity as herbicide or algaecide, herbicide and algaecide compositions
Bonneau, A.-L.; Botte, C.; Deligny, M.; Saidani, N.; Hardre, H.; Rousseau, B.; Lopez, R.; Marechal, E. WO2008146174
Publications
1. ENT1 inhibition enhances weight control and metabolic health in diet-induced obesity.
Lucas Chaible, Julie Preillon, Charlotte Philippart, Alizée Canevat, Laura Saerens, Dimitri Kondratow, Michael Deligny, Alexis Goffaux, Anne-Catherine Michaux, Marie-Claire Letellier, Nicolas Rosewick, David Carbonez, João Marchante, Francesco Strozzi, Erica Houthuys, Reece Marillier, Yvonne McGrath, Steven Van der Plas, Alexander Pfeifer & Julie Chesné Biomedicine & Pharmacotherapy
2. Inhibition of A2AR alleviates adenosine-mediated suppression of plasma cell differentiation.
Paola Tieppo, Hussein Shehade, Chiara Martinoli, Marjorie Mercier, David Carbonez, Nicolas Rosewick, Sophie Jung, Anais Vezzu, Boris Pirlot, Noemie Wald, Stephanie Ma, Lucas Chaible, Reece Marillier, Francesco Strozzi, Marie-Caroline Dieu-Nosjean, Joao Marchante, Margreet Brouwer, Erica Houthuys, Michael Deligny, Yvonne McGrath & Maura Rossetti Frontier in Immunology (2025)
3. Inhibition of ENT1 relieves intracellular adenosine-mediated T cell suppression in cancer.
Theodore J. Sanders, Christopher S. Nabel, Margreet Brouwer, Annelise L. Hermant, Lucas Chaible, Jean-Philippe Deglasse, Nicolas Rosewick, Angélique Pabois, Wilfried Cathou, Aurore Smets, Michael Deligny, João Marchante, Quentin Dubray, Marie-Claire Letellier, Chiara Martinoli, Reece Marillier, Olivier De Henau, Yvonne McGrath, Matthew G. Vander Heiden & Erica Houthuys Nature immunology (2025)
4. Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolone analogs
Saidani, Nadia; Botte, Cyrille Y.; Deligny, Michael; Bonneau, Anne-Laure; Reader, Janette; Lasselin, Ronald; Merer, Goulven; Niepceron, Alisson; Brossier, Fabien; Cintrat, Jean-Christophe; Rousseau, Bernard; Birkholtz, Lyn-Marie; Cesbron-Delauw, Marie-France; Dubremetz, Jean-Francois; Mercier, Corinne; Vial, Henri; Lopez, Roman; Marechal, Eric Antimicrobial Agents and Chemotherapy (2014), 58(5), 2586-2597
5. Chemical inhibitors of monogalactosyldiacylglycerol synthases in Arabidopsis thaliana
Botte, Cyrille Y.; Deligny, Michael; Roccia, Aymeric; Bonneau, Anne-Laure; Saidani, Nadia; Hardre, Helene; Aci, Samia; Yamaryo-Botte, Yoshiki; Jouhet, Juliette; Dubots, Emmanuelle; et al Nature Chemical Biology (2011), 7(11), 834-842
6. Stereoselective synthesis of (+)-goniodiol, (+)-goniotriol, (-)-goniofupyrone, and (+)-altholactone using a catalytic asymmetric hetero-Diels-Alder/allylboration approach
Favre, Annaick; Carreaux, Francois; Deligny, Michael; Carboni, Bertrand European Journal of Organic Chemistry (2008), (29), 4900-4907
7. (E)-α-Substituted γ-Alkoxyallylboronic Esters as New Reagents: Synthesis and Reactivity toward Aldehydes
Posseme, Francoise; Deligny, Michael; Carreaux, Francois; Carboni, Bertrand Journal of Organic Chemistry (2007), 72(3), 984-989
8. Catalytic Enantioselective Three-Component Hetero-[4+2] Cycloaddition/Allylboration Approach to α-Hydroxyalkyl Pyrans: Scope, Limitations, and Mechanistic Proposal
Gao, Xuri; Hall, Dennis G.; Deligny, Michael; Favre, Annaick; Carreaux, Francois; Carboni, Bertrand Chemistry--A European Journal (2006), 12(11), 3132-3142
9. A concise synthesis of (+)-goniodiol using a catalytic hetero Diels-Alder/allylboration sequence
Deligny, Michael; Carreaux, Francois; Carboni, Bertrand Synlett (2005), (9), 1462-1464
10. A novel diastereoselective route to -hydroxyalkyl dihydropyrans using an hetero Diels-Alder/allylboration sequence
Deligny, Michael; Carreaux, Francois; Carboni, Bertrand; Toupet, Loic; Dugardin, Gilles Chemical Communications (2003), (24), 276-277
11. Efficient asymmetric synthesis of 2,6-disubstituted 2H-dihydropyrans via a catalytic hetero-dielsalder/allylboration sequence
Deligny, Michael; Carreaux, Francois; Toupet, Loic; Carboni, Bertrand Advanced Synthesis & Catalysis (2003), 345(11), 1215-1219